circtools 2.0 released!

Feb 2025

We are proud to release circtools 2.0 on GitHub and the accompanying paper on bioRxiv in collaboration with the Dieterich Lab.

Circtools 2.0 features 4 completely new modules for computational circular RNA research:

  • conservation module: enables users to perform circRNA conservation analysis in five widely studied animal model species: mouse, human, rat, pig, and dog.
  • padlock probe design: a specialized primer design tool tailored specifically for next-generation spatial transcriptomics technology.
  • nanopore module: requires sequencing reads that have been produced using the protocol outlined in Rahimi et al. (2021) and enables full-length circRNA detection.
  • metatool module: offers integration of circularRNA predictions from CIRIquant to boost recall rates for circRNA detection.
Tobias Jakobi
Tobias Jakobi
Assistant Professor

Bioinformatician interested in circular RNAs in the heart.